In 1993, Isuzu halted production of the Gemini and replaced it with a rebadged version of the Honda Domani. Announced at the end of August it went on sale in early September 1993. Isuzu did not really advertise the new Gemini; it was mainly produced to be sold to existing customers of Isuzu's commercial vehicles. It was only available with the four-door sedan bodystyle and a limited number of engines; the Domani also came as a five-door hatchback.

The models at the time of introduction were the 1600 C/C, C/C 4WD, and the slightly more powerful and better equipped G/G model. Maximum power output is 120 PS (88 kW) at 6,300 rpm for the C/C and 120 PS (88 kW) at 6,400 rpm for the G/G. In May 1995 the E-VTEC equipped 1500 C/C model was added to the lineup; this fuel efficient, lean-burn model was aimed at capturing some of the old buyers of diesel-engined Geminis. Diesels had accounted for about half of Gemini sales for the previous generations. The 1500 C/C has a maximum power of 94 PS (69 kW) at 5,500 rpm.^[28] In October 1995, the Gemini underwent some very minor changes in equipment and the 1600 C/C engine was lightly modified. Most notably, the "Gemini" sticker on the front doors was changed to a plastic emblem. Production of the fourth-generation Gemini ended in January 1997 and it was replaced the following month.